Dopamine (Intropin) for hypotension
Clonidine (Catapres) for HTN
Receptors
Dopamine (Intropin) - DA, alpha 1, beta 1
Clonidine (Catapres) - alpha 2 in CNS
Why it works?:
Dopamine is used for hypotension while other vasopressors are not. Why? Phenyl-ephrine is too strong as alpha vasoconstrictors that it's not used. NorEpi with its effects on beta receptors also increase heart rate which is not preferrable for a person who is hypotensive. Why would a hypotensive persons shouldn't have increase heart rate? Look this hypotensive person is not in shock yet, the heart is still beating fast already. However, you don't want the heart to beat that fast in hypotensive, so you want to give Dopamine.
Clonidine works because it activates alpha 2 receptors in CNS. Remember that while alpha 2 receptors in periphery cause vasoconstriction, in the CNS they cause vasodilation leading to reducing the tension in the CNS pressures. Super helpful for HTN cerebral patients.
~Wonder Me!
Clonidine (Catapres) for HTN
Receptors
Dopamine (Intropin) - DA, alpha 1, beta 1
Clonidine (Catapres) - alpha 2 in CNS
Why it works?:
Dopamine is used for hypotension while other vasopressors are not. Why? Phenyl-ephrine is too strong as alpha vasoconstrictors that it's not used. NorEpi with its effects on beta receptors also increase heart rate which is not preferrable for a person who is hypotensive. Why would a hypotensive persons shouldn't have increase heart rate? Look this hypotensive person is not in shock yet, the heart is still beating fast already. However, you don't want the heart to beat that fast in hypotensive, so you want to give Dopamine.
Clonidine works because it activates alpha 2 receptors in CNS. Remember that while alpha 2 receptors in periphery cause vasoconstriction, in the CNS they cause vasodilation leading to reducing the tension in the CNS pressures. Super helpful for HTN cerebral patients.
~Wonder Me!
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