1.carbamezepine, oxcarbazepine, eslicarbazepine: Tricyclic compounds; Fatal derm rxns (SJS/TEN) ===> Test for HLA-B*1502 prior to therapy
2.clobazam: Drug class: BZD; Lennox-Gastaut syndrome
3.clonazepam: Absence seizures; Drug class: BZD; Myoclonic seizures:
4.Clorazapate: adjunct for complex partial sz (adults);
5.Diazepam/Lorazepam: Drug class: BZD; status epilepticus
6.Ezogabine/Retigabine: vision loss, refractory seizures
7.felbamate: drug of last choice for partial seizures (Black box of fatal hepatoxic) - Not administered until a complete discussion of the risks; patient/parent/guardian & the physician sign acknowledgment form
8.fosphenytoin: Dosed in phenytoin equivalents; has a blackbox warning: may cause hypotension/arrhythmia ==> cannot give too fast: giving too fast
9.Gabapentin: adjunct for partial & tonic-clonic;
10.Lacosamide: mono or adjunct for partial seizures; Na channel; Scheduled: V
11.lamotrigine: life-threatening rash; Na channel agent; adjunct for Lennox Gastaut, partial & tonic-clonic seizures
12.Levetiracetam: minimal drug-drug effects; adjunct for partial & generalized
13.Pentobarbital: Barbituate; refractory seizures
14.Perampanel: serious/life-threatening psych. & behavioral issues, adjunct for partial
15.Phenytoin: treat all seizures but absence
Mech: sodium
Common side effects: rash, nausea, gingival hyperplasia, neuro (ataxia, diplopia, nystagmus)
Serious side effects: hepatotoxicity & myelosuppression
Monitoring: drug-drug (cyp450-hepatotoxicity), drug levels
Mech: sodium
Common side effects: rash, nausea, gingival hyperplasia, neuro (ataxia, diplopia, nystagmus)
Serious side effects: hepatotoxicity & myelosuppression
Monitoring: drug-drug (cyp450-hepatotoxicity), drug levels
16.Pregabalin: partial seizures; Mech.: GABA
17.Primidone: Barbituate; generalized tonic-clonic seizures, partial seizures; metabolized to barbitals
18.Rufinamide: Na channel agents; Lennox-Gastaut syndrome adjunct;
19.tiagabine: adjust dose for hepatic functions; adjunct of partial seizures
20.Topiramate: baseline serum bicarb & eGFR before therapy; dose adjustment for renal impairment; partial, generalized, Lennox Gastaut
21.Valproic acid: primary for generalized & partial seizures; several drug-drug interaction levels => monitor drug levels
22.Vigabentrin: Vision Loss => REMs, available only thru SHARE special programs; GABA derivatives
23.Zonisamide: check for sulfa allergy (sulfonamide allergies); adjunct for generalized or partial seizures; Sodium agents
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