II
– Bile Acids Binders
Cholestyramine,
Colesevelam, Colestipol
∴Binds to bile acids in the colon
(intestines) => reduce bile acids available => negative feedbacks =>
liver tries to get more cholesterol to make bile acids => removes
cholesterol from blood (cholesterol catabolism)
Mnemonics
for mech.: the coast guard, the servant, and the
Interpol of the colon work to bind to the bile acids that prevent the criminals
(Cholesterol) from coming ashore (out from the intestines)
Mnemonics:
CHOLEST-
Cholestyramine ---- CHOLEST-styramine
Colesevelam --------COLES-evelam
Colestipol (Colestid) ----COLEST-ipol---
Mnemonics – the drugs
all have choles or coles in it => they work to lower Cholesterol
COL-
Cholestyramine ---- CHOL-est-styramine---COLON-coast-guard-STYMIES-
Colesevelam --------COL-es-evelam--------COLON-e-servant-lam
Colestipol (Colestid) ----COL-est-ipol--------- COLON-Inte-POL
Mnemonics- the drugs
start with 'chol' meaning they work in the colon
Once you know their
mode of action, you can figure out what happens to the VLDL, LDL, & HDL.
Side effects (GI): constipation,
dyspepsia, bloating, stomach cramps, abdominal distension, obstruction
Why it works: bc they
work at the Colon => you can imagine, lots of GI problems => may create
malsorption of fat-soluble vitamins because they won’t bind to bile acids =>
create malsorption of A-D-E-K vitamins
Mnemonics for
fat-soluble vitamins: "the fat cat is in the
ADEK". In this scenario, the word "fat" should remind you that
the grouping is of fat-soluble vitamins, with ADEK representing the first
letter of each.
Contraindicated when
TG > 300 mg/dL
Mnemonics for TG>300:
when the trio gangsters of 300lbs => tri = 300 => the
trio gangsters know that the criminals (cholesterols) are being attacked. They
know the Interpol, the coast-guards stigmies, and the servants are weakend
because they are focusing on the those guys. Therefore, the trio gangsters will
become stronger. When they exceed their 300lbs, they are so dangerous that the Interpol
can’t be used on the colon anymore.
Use in adjunct => of course, these intepols, servants & coast guard stygmies
need help from the vast-statues to really have huge and big effects not just at
the colon but also right at the jail (liver)
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