1. | Amantadine | | Mech.: potentiates DA actions by some unclear mech. |
2. | benztropine | | 1st Anti-Cholinergic; parkinson's; improve tremor & rigidity; little effect on bradykinesia; titrate up until symptoms improve; taper slowly |
3. | biperiden | | 2nd Anti-Cholinergic; parkinson's; improve tremor & rigidity; little effect on bradykinesia; titrate up until symptoms improve; taper slowly |
4. | bromocriptine | | 1st drug in the monotherapy for mild dz; or combined with DA; Side effects similar to DA BUT bc it's just a supporter, it's quickly prohibited in ppl with psychotic illness or active peptic ulcer; parkinson's med |
5. | Carbidopa/Levodopa | | metabolized to DA; Most effective; >75y/o; use with COMT/MAOI = longer effects; parkinson's med |
6. | diphenhydramine | | 3rd Anti-Cholinergic; parkinson's; improve tremor & rigidity; little effect on bradykinesia; titrate up until symptoms improve; taper slowly |
7. | entacapone | | COMT-I; parkinson's med; Diminishes Levodopa levels in peripheral metabolism |
8. | pramipexole | | 2nd drug in the monotherapy for mild dz; or combined with DA; Side effects similar to DA BUT bc it's just a supporter, it's quickly prohibited in ppl with psychotic illness or active peptic ulcer; parkinson's med |
9. | rasagiline | | MAO-I; more potent than selegiline; inhibitor of the DA uptake pump; adjunct only; parkinson's med |
10. | ropinirole | | 3rd drug in monotherapy for mild dz; or combined with DA;Side effects similar to DA BUT bc it's just a supporter, it's quickly prohibited in ppl with psychotic illness or active peptic ulcer ; parkinson's med |
11. | Selegiline | | MAO-I; inhibitor of the DA uptake pump; adjunct only; parkinson's med |
12. | tolcapone | | COMT-I; Liver toxic => pt to sign consent; parkinson's med; Diminishes Levodopa levels in peripheral metabolism |
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