Pathophys:
- motor area of cerebral cortex damage
Causes:
- spinal injury
- trauma
- neuro-degenerative injury
- dystonia
Symptoms:
- muscle spasm
- spasticity
Drug therapy:
- skeletal muscle relaxant
- direct-acting anti-spasmodics
- neuro-muscular blocking agents:
Drug names:
1 - Skeletal muscle relaxant:
- baclofen ---- BACK-lo-pha^.n => relax ur back, let baclofen work for you
- carisoprodol---Carries-all-professional=> no need to worry about anything => relax muscles, let them work
- methocarbamol--Mentos-eaten-in-car-relaxes-kamol before seeing his date
- tizanidine---seeing-tarzan-makes-jane-relaxe
2 - Direct-acting anti-spasmodics:
- OnabotulinumtoxinA => stop spasm. Don't give over 360units/3mo
- Dantrolene ----(denture-lion=frozen in scare => cannot move anymore, even tho before was shaking like crazy) ---100mg/4x/day
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