Cholesterol
Absorption Inhibitor
Ezetimibe
Mech.: inhibit absorption of cholesterol by the small
intestine
Mnemonics for mech.:
-
I just think of it acting according to the EZest mechanism out
there. The drug doesn't bother entering the blood, hepatocytes, or endothelial
cells; it just stays in the GI and does its work there.
History background: At first, when this drug first
come out, it was thought to be sooo cool. This is bc while vastatin only lower
cholesterol by 6%. This drug is able to lower by like 80% of triglycerides alone.
Using with vastatin, if you need to increase dosage for the right effect, it
would be double triple the dose running the higher side effects => stocks
went sky high for the drugs. However, after the RCT’s showed that the drugs
does not really have any great outcomes despite its mechanism, stocks
plummetted
Mnemonics for name: E-z-e-timid-tribe
=> the easy timid tribe takes up only a small areas = small intestines. It’s so timid = not much needed to get the
criminals away. It’s a tribe trying to get the criminals (cholesterol)
away from its small intestines land bc they don’t want any criminals on their
land.
Therefore => Use:
- in combo w/
vastatin when pts unable to achieve
target LDL: ezetimabide/simvastatin
- Or, in pt intolerant w/
vastatin
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