Psyllium < Polycarbophil < Methylcellulose
natural < semi-synthetic < synthetic
Methyl cellulose does not cause much flatulence as other products. Think: all synthetic => less side effects.
MOA (Mechanism of Action): These agents swell & distend the colons. Meaning, these agents are substances that are very gelatinous (colloids) that absorb water. Therefore, you'll need to drink water when taking these agents. These agents absorb water and cause a softening of stool mass. In addition, the bulk-forming laxatives cause an enlargement of the stools that stimulates propulsive movements in the GI tract and encourages the passage of intestinal contents (1).
Analogy: think of these bulk-forming agents like the agar powder you use to make agar gel (jello!). What do you need? water! If you just take those powder without water. What does it do? These powder may just stick to your esophagus or GI without water. Thus, you'll need water to have those agents bulk up like a real gel.
Place in therapy: maintenance therapy (in digestible)
Mnemonics:
cellulose => indigestible => laxative
Psy sings Polly's got a car she loves must've met the sell-or-lose criteria working hard to bulk up his belly. He looks constipated!
Psy: psy singer => Psyllium
Polly's got a car she loves: Polycarbophil
Met the sell or lose: Methylcellulose
Bulk: bulking agents
(1): http://pharmacy.utah.edu/pharmtox/common_meds/icm15.html
(2): https://books.google.com/books?id=XT3eAAAAQBAJ&pg=PA67&lpg=PA67&dq=Psyllium++Polycarbophil++Methylcellulose+mnemonics&source=bl&ots=UcfnsRHYp9&sig=Wz46D_hXvMRfGDKtfiwCgU2HImU&hl=en&sa=X&ved=0ahUKEwjAnNTX9sbMAhUK4mMKHcofBjoQ6AEIHDAA#v=onepage&q=Psyllium%20%20Polycarbophil%20%20Methylcellulose%20mnemonics&f=false
natural < semi-synthetic < synthetic
Methyl cellulose does not cause much flatulence as other products. Think: all synthetic => less side effects.
MOA (Mechanism of Action): These agents swell & distend the colons. Meaning, these agents are substances that are very gelatinous (colloids) that absorb water. Therefore, you'll need to drink water when taking these agents. These agents absorb water and cause a softening of stool mass. In addition, the bulk-forming laxatives cause an enlargement of the stools that stimulates propulsive movements in the GI tract and encourages the passage of intestinal contents (1).
Analogy: think of these bulk-forming agents like the agar powder you use to make agar gel (jello!). What do you need? water! If you just take those powder without water. What does it do? These powder may just stick to your esophagus or GI without water. Thus, you'll need water to have those agents bulk up like a real gel.
Place in therapy: maintenance therapy (in digestible)
Mnemonics:
cellulose => indigestible => laxative
Psy sings Polly's got a car she loves must've met the sell-or-lose criteria working hard to bulk up his belly. He looks constipated!
Psy: psy singer => Psyllium
Polly's got a car she loves: Polycarbophil
Met the sell or lose: Methylcellulose
Bulk: bulking agents
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| Psy sings Polly's got a car she loves must've met the sell-or-lose criteria. He's working hard to bulk up his belly. He looks constipated! |
(1): http://pharmacy.utah.edu/pharmtox/common_meds/icm15.html
(2): https://books.google.com/books?id=XT3eAAAAQBAJ&pg=PA67&lpg=PA67&dq=Psyllium++Polycarbophil++Methylcellulose+mnemonics&source=bl&ots=UcfnsRHYp9&sig=Wz46D_hXvMRfGDKtfiwCgU2HImU&hl=en&sa=X&ved=0ahUKEwjAnNTX9sbMAhUK4mMKHcofBjoQ6AEIHDAA#v=onepage&q=Psyllium%20%20Polycarbophil%20%20Methylcellulose%20mnemonics&f=false
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