TNF caused inflammation in the intestines.
http://www.hindawi.com/journals/mi/2014/325129/
Anti-tumor necrosis factor (anti-TNF) drugs are a class of drugs that are used worldwide to treat inflammatory conditions. These drugs are able to reduce inflammation and stop disease progression. TNF is a chemical produced by the immune system that causes inflammation in the body. In healthy individuals, excess TNF in the blood is blocked naturally, but in those who have rheumatic conditions, higher levels of TNF in the blood lead to more inflammation and persistent symptoms. - See more at: http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Anti-TNF#sthash.lHeh5Bk1.dpuf -
The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,[2] cancer,[3] major depression,[4] Psoriasis[5] and inflammatory bowel disease (IBD).[6] While still controversial, studies of depression and IBD are currently being linked to TNF levels.[7]
Impaired cell death program has been noted as one of the hallmarks of chronic lymphocytic leukemia (CLL) and contributes to its accumulation of malignant monoclonal B cells as well as to chemotherapy resistance. A cell can die through the apoptosis or necrosis pathway. Recent investigations suggest that in apoptotic-deficient conditions, such as most types of cancer, a process of programmed necrosis, called necroptosis, prevails. source: http://www.nature.com/leu/journal/v26/n6/full/leu2011357a.html
http://www.hindawi.com/journals/mi/2014/325129/
Anti-tumor necrosis factor (anti-TNF) drugs are a class of drugs that are used worldwide to treat inflammatory conditions. These drugs are able to reduce inflammation and stop disease progression. TNF is a chemical produced by the immune system that causes inflammation in the body. In healthy individuals, excess TNF in the blood is blocked naturally, but in those who have rheumatic conditions, higher levels of TNF in the blood lead to more inflammation and persistent symptoms. - See more at: http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Anti-TNF#sthash.lHeh5Bk1.dpuf -
The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,[2] cancer,[3] major depression,[4] Psoriasis[5] and inflammatory bowel disease (IBD).[6] While still controversial, studies of depression and IBD are currently being linked to TNF levels.[7]
Impaired cell death program has been noted as one of the hallmarks of chronic lymphocytic leukemia (CLL) and contributes to its accumulation of malignant monoclonal B cells as well as to chemotherapy resistance. A cell can die through the apoptosis or necrosis pathway. Recent investigations suggest that in apoptotic-deficient conditions, such as most types of cancer, a process of programmed necrosis, called necroptosis, prevails. source: http://www.nature.com/leu/journal/v26/n6/full/leu2011357a.html
|
Post a Comment