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Finasteride’s effect on PSA

In patients with BPH, finasteride decreases PSA levels by about half. This phenomenon occurs even if a man taking the drug for BPH has prostate cancer. As a result, actual PSA levels for men in the finasteride arm of the PCPT study were doubled to approximate their true PSA.
Because the hair-loss drug Propecia is a form of finasteride, it may also lower PSA levels, and men taking it should alert their health care providers. An artificially low, unadjusted PSA level can delay a biopsy and thus the discovery of prostate cancer.

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