Naming:
-olol: beta blockers
propano-: pro panel = prototype = oldest beta blocker (BEFORE the invention of atenolol which is a very old drug)
Receptors:
non-selective beta blocker => blocks beta1 and beta 2
Use:
- HTN -------- by reducing HR via beta 1 blocking
- Dysrhythmias --------by reducing heart rate via beta 1 blocking
- Essential Tremors -----not well understood about the pathophys of Essential Tremors nor how Propranolol works well in ET (tho may not resolve essential tremor entirely).(2)
History:
Propranolol was discovered in 1964 (BEFORE the invention of atenolol which is a very old drug) (1)
HTN: Half life: 2-3 hrs IV (2) => NOT useful for HTN emergencies due to long half-life
(1) from wikipedia for propranolol: Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 331. ISBN 9783527326693.
(2) George CF, Fenyvesi T, Conolly ME, et al: Pharmacokinetics of dextro, levo, and racemic propranolol in man. Eur J Clin Pharmacol 1972; 4:74.
-olol: beta blockers
propano-: pro panel = prototype = oldest beta blocker (BEFORE the invention of atenolol which is a very old drug)
Receptors:
non-selective beta blocker => blocks beta1 and beta 2
Use:
- HTN -------- by reducing HR via beta 1 blocking
- Dysrhythmias --------by reducing heart rate via beta 1 blocking
- Essential Tremors -----not well understood about the pathophys of Essential Tremors nor how Propranolol works well in ET (tho may not resolve essential tremor entirely).(2)
History:
Propranolol was discovered in 1964 (BEFORE the invention of atenolol which is a very old drug) (1)
HTN: Half life: 2-3 hrs IV (2) => NOT useful for HTN emergencies due to long half-life
(1) from wikipedia for propranolol: Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 331. ISBN 9783527326693.
(2) George CF, Fenyvesi T, Conolly ME, et al: Pharmacokinetics of dextro, levo, and racemic propranolol in man. Eur J Clin Pharmacol 1972; 4:74.
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