Drug class: Hydantoins
Drug name: fosphenytoin (fos-phenytoin)
Note:
- A derivative of Phenytoin => newer <=> better <=> potentially more safely than intravenous phenytoin (1)
- Dosed in phenytoin equivalents (One millimole of phenytoin is produced for every millimole of fosphenytoin administered (1))
- has a blackbox warning: may cause hypotension/arrhythmia ==> cannot give too fast: giving too fast can cause CVS issues
History:
Use:
References:
(1): https://en.wikipedia.org/wiki/Fosphenytoin
Drug name: fosphenytoin (fos-phenytoin)
Note:
- A derivative of Phenytoin => newer <=> better <=> potentially more safely than intravenous phenytoin (1)
- Dosed in phenytoin equivalents (One millimole of phenytoin is produced for every millimole of fosphenytoin administered (1))
- has a blackbox warning: may cause hypotension/arrhythmia ==> cannot give too fast: giving too fast can cause CVS issues
 |
| Picmonic: Fos-phenytoin <=> Fox before the cow |
| Mnemonics for BlackBoxWarning: when phenytoin has to carry a fox (fos-phenytoin), the fox is mean like the nine-tail-fox that sucks the steers-phenytoin blood away causing hypotension and arrythmias. |
 |
| BlackBoxWarning: Fos-Phenytoin <=> 9-tailed Fox = sucking blood causing hypotension & arrhymias |
(1): Simply putting patients on other drugs is not always an option; this was especially true before 1993, when the number of anticonvulsants available was much more limited. One solution was to develop a prodrug that did not have these drawbacks.
Fosphenytoin was approved by the Food and Drug Administration (FDA) on August 5, 1996 for use in epilepsy.
Use:
- short term (five days or fewer) treatment of epilepsy when more widely used means of phenytoin administration are not possible or are ill-advised, such as endotracheal intubation,
- status epilepticus or some other type of repeated seizures;
- vomiting,
(1): https://en.wikipedia.org/wiki/Fosphenytoin
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