Wonder Me!
most likely the public will be unlikely to use it if severe side effects known.

This one is different from Phase 4. Phase 4 is only 100,000's target patients. This one is everybody all over the place.

Medwatch & Dear Health Care Professionals

Ex: Tacrolimus is an immunosuppressant drug that is used in organ transplant. It is then approved by FDA to treat atopic dermatitis. Then, they realize it can cause skin cancer. Then, consumers don't want to use this drug that much anymore. However, it's still a common drug for transplant pt (these pt are very sick they need organ and drugs to help their body). Of course, use of this drug in children is much more limited.
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